ABSTRACT
To mitigate the spread of novel coronavirus, how to optimise COVID-19 medical waste location-transport strategies remains an open but urgent issue. In this paper, a novel digital twin-driven conceptual framework is proposed to improve the strategic decision on the location of temporary disposal centres and, subsequently, the operational decision on the transport of COVID-19 medical waste in the presence of hierarchical relationships amongst stakeholders, circular economy, uncertainty in infection probability, and service level. The circular economy aspect is measured by the reduction of infection risks and costs, as well as limiting exhaust emissions. The polyhedral uncertainty set is introduced to characterise stochastic infection probability. Digital twin technology is further used to estimate the upper and lower bound of the uncertainty set. Such a problem is formulated as a digital twin-driven robust bi-level mixed-integer programming model to minimise total infection risks on the upper level and total costs on the lower level. A hybrid solution strategy is designed to combine dual theory, Karush-Kuhn-Tucker (KKT) conditions, and a branch-and-bound approach. Finally, a real case study from Maharashtra in India is presented to evaluate the proposed model. Results demonstrate that the solution strategy performs well for such a complex problem because the CPU time required to conduct all experiments is less than one hour. Under a given uncertainty level of 36 and perturbation ratio of 20%, a regional transport strategy is preferred from generation points to transfer points, while a cross-regional one is usually implemented from transfer points to disposal centres. It is of significance to determine the bound of available temporary disposal centres. Using digital technology (e.g., digital twin) to accurately estimate the amount of COVID-19 medical waste is beneficial for controlling the pandemic. Reducing infection risks relative to cost is the prioritised goal in cleaning up COVID-19 medical waste within a relatively long period.
ABSTRACT
A safe and effective medical waste transport network is beneficial to control the COVID-19 pandemic and at least decelerate the spread of novel coronavirus. Seldom studies concentrated on a two-phase COVID-19 medical waste transport in the presence of multi-type vehicle selection, sustainability, and infection probability, which is the focus of this paper. This paper aims to identify the priority of sustainable objectives and observe the impacts of multi-phase and infection probability on the results. Thus, such a problem is formulated as a mixed-integer programming model to minimise total potential infection risks, minimise total environmental risks, and maximise total economic benefits. Then, a hybrid solution strategy is designed, incorporating a lexicographic optimisation approach and a linear weighted sum method. A real-world case study from Chongqing is used to illustrate this methodology. Results indicate that the solution strategy guides a good COVID-19 medical waste transport scheme within 1 min. The priority of sustainable objectives is society, economy, and environment in the first and second phases because the total Gap of case No.35 is 3.20%. A decentralised decision mode is preferred to design a COVID-19 medical waste transport network at the province level. Whatever the infection probability is, infection risk is the most critical concern in the COVID-19 medical waste clean-up activities. Environmental and economic sustainability performance also should be considered when infection probability is more than a certain threshold.
ABSTRACT
The world is witnessing the COVID-19 pandemic, which originated in the city of Wuhan, China, and has quickly spread to the whole world, with many cases having been reported in India as well. The healthcare system is going through unprecedented load on its resources while the available infrastructure is inadequate.COVID-19 samples are being tested at a massive scale and even small optimizations at this scale can save time, huge amounts of money, and resources. Particularly, the manual approach or even baseline greedy approach being used to allocate COVID-19 samples to medical labs across a state can lead to underutilization of resources. Hence, this work proposes a system to optimize the problem of allocation of medical samples to medical testing laboratories with high efficiency and minimal economic penalty. We use the Mixed Integer Programming (MIP) Model using high-performance MIP based solvers for custom applications by providing a tight integration with the branch-and-cut algorithms of the supported solvers to improve the results compared to baseline greedy approach. The system provides a transportation schedule optimized with respect to capacity of different labs and COVID-19 cases across the state of Karnataka. We tested the model on various datasets and observed significant improvement over the baseline greedy model.
ABSTRACT
This study presents a new risk-averse multi-stage stochastic epidemics-ventilator-logistics compartmental model to address the resource allocation challenges of mitigating COVID-19. This epidemiological logistics model involves the uncertainty of untested asymptomatic infections and incorporates short-term human migration. Disease transmission is also forecasted through a new formulation of transmission rates that evolve over space and time with respect to various non-pharmaceutical interventions, such as wearing masks, social distancing, and lockdown. The proposed multi-stage stochastic model overviews different scenarios on the number of asymptomatic individuals while optimizing the distribution of resources, such as ventilators, to minimize the total expected number of newly infected and deceased people. The Conditional Value at Risk (CVaR) is also incorporated into the multi-stage mean-risk model to allow for a trade-off between the weighted expected loss due to the outbreak and the expected risks associated with experiencing disastrous pandemic scenarios. We apply our multi-stage mean-risk epidemics-ventilator-logistics model to the case of controlling COVID-19 in highly-impacted counties of New York and New Jersey. We calibrate, validate, and test our model using actual infection, population, and migration data. We also define a new region-based sub-problem and bounds on the problem and then show their computational benefits in terms of the optimality and relaxation gaps. The computational results indicate that short-term migration influences the transmission of the disease significantly. The optimal number of ventilators allocated to each region depends on various factors, including the number of initial infections, disease transmission rates, initial ICU capacity, the population of a geographical location, and the availability of ventilator supply. Our data-driven modeling framework can be adapted to study the disease transmission dynamics and logistics of other similar epidemics and pandemics.